(Annisa) 4 : 156
وَبِكُفْرِهِمْ وَقَوْلِهِمْ عَلَىٰ مَرْيَمَ بُهْتَانًا عَظِيمًا

And due to their disbelief, and uttering upon Maryam severe slander.

Due to the disbelief of Jews about the Lord and His Book, Lord had sealed their hearts. So when Maryam conceived Jesus as a divine Miracle, they were uttering slander upon Maryam that she was strayed. They didn’t approve of her and her son Jesus. The Three-Time-Knowledge Adhikr is revealed to rectify the deviation of previous people and to teach mankind the aim of life. 

The people of the last Messenger who inherited the last version of the Book have the responsibility to testify and propagate Adhikr which is the Food, Cloth, and Sight of the human soul as told in verse 35: 32. But the Fujjar by hiding and rejecting Adhikr are more strayed than any other people all around the world. They are having evil concepts about Lord, His Book, His Messengers and Prophets, Angels, and the Hereafter. They are hurrying for the emergence of Antichrist by involving in all heinous and mischievous activities. It is told in verse 63: 3: "Since their hearts are sealed, the Fujjar will never return into the aim of life". The Fujjar will witness against their soul that indeed they were disbelievers at the time of death vide verse 7: 37, and on the Day of Judgment vide verse 6: 130. It is told in verse 11: 17 that whoever from the different groups of Fujjar hide Adhikr, he is promised with the Fire. 

It is warned in verse 63: 9: "Oh you who believed, neither your wealth nor your children should obstruct you from Adhikr if anyone does so, those are the losers". See explanation 2: 18, 121; 6: 25; 7: 127 and 137.