And verily We had given Moses the Book, and followed him up with a series of Messengers. We gave Jesus, the son of Maryam, Manifest Evidence and strengthened him with the Holy Spirit. Whenever a Messenger comes to you with what you don’t like, you become so arrogant! Then you rejected some of them, and you are killing some of them.
This verse addresses the Jews and Christians at the time of Messenger Muhammad. All the Messengers including Moses, Jesus, Dawood, etc. were sent down with Adhikr which is the Proof and Truth as told in verses 16: 44; 21: 24, and 41: 43. After Moses, Jews deviated from the Book and were differentiated into different groups. Then Jesus was sent to them, but they rejected him and the Book with Explanations sent with him which was against their whims. Then they even boasted that they crucified and killed Jesus. But Lord raised Jesus bodily into the second Heaven as explained in verse 4: 158. They had killed some Prophets and had tried to kill some Messengers.
Today Jews, Christians, or others are not killing any Prophet or Messenger. But the Arabic Quran reading Fujjar who hide and reject Adhikr are adapting the names and costumes of Prophets and Messengers without witnessing their life before mankind. By doing so they are not following any Messenger or Prophet, instead, they are following twenty-nine pseudo-prophets and are welcoming the Antichrist. They are denoted as the worst creatures not because of being deaf and dumb towards the Arabic Quran, but towards Adhikr as told in verse 8: 22.
‘The Holy-Spirit’ refers to the Angel Jibreel. As Angel Jibreel is always with Jesus, Satan or anyone can’t approach or harm him with bad aim. The second coming of Jesus is one of the Crucial Signs of Doomsday. The Fujjar who will approve Antichrist as a prophet and the lord if they are affected by the breath of Jesus will collapse as explained in verse 4: 159. See explanation 2: 62, 253; 4: 150-151; 5: 110 and 10: 103.